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Final Score: San Diego 5 - Cleveland 9

Cleveland, OH (Sports Network) - Grady Sizemore hit a pair of home runs separated by nearly five hours, and the Cleveland Indians came back for a 9-5 win over the San Diego Padres in the rain-soaked opener of a three-game interleague series that took six hours and 15 minutes to complete.

The game featured a rain delay of nearly three hours in the bottom of the first inning, but the decision was made to try and finish the contest.

Kelly Shoppach added a two-run homer for the Indians, who have won four of their last five games. Shin-Soo Choo knocked in the go-ahead runs with a single in the sixth, while Jamey Carroll went 3-for-5 and knocked in a run.

Rafael Betancourt (2-3) tossed 1 2/3 innings of shutout ball to earn the win in relief of Jeremy Sowers, who allowed four runs on nine hits in 4 1/3 frames.

Kevin Kouzmanoff and Adrian Gonzalez each homered and drove in two runs for the Padres, who had a two-game win streak halted and lost for just the second time in their last nine games. Khalil Greene knocked in the other run in the losing effort.

Cla Meredith (0-2) allowed two runs in the sixth, dropping the decision in relief of Josh Banks, who allowed three runs on five hits in five innings. The San Diego bullpen was tagged for six runs on seven hits in three innings, issuing six walks.

With Meredith on for Banks in the sixth trying to preserve a 4-3 lead, the Tribe pieced together a threat. Ben Francisco reached on an infield single with one out, and Ryan Garko moved him to second with a single to right. After David Dellucci flew out, Jhonny Peralta walked to load the bases. Choo followed by hooking a grounder past Gonzalez and into right for a go-ahead, two-run single.

The Indians pulled away against reliever Mike Adams in the seventh, as Shoppach worked a leadoff walk and Sizemore crushed his second homer of the game, a tape-measure blast to right. Singles by Carroll and Garko put runners on the corners with one out, but the Indians failed to tack on any more insurance.

Kouzmanoff cut the lead to 7-5 in the top of the eighth, crushing to one-out homer to left off Rafael Perez. After Perez retired Greene, Masa Kobayashi came on and retired the side.

Carroll pushed the lead back to three with a bases-loaded single in the home half, and Francisco lofted a sacrifice fly for a 9-5 lead, while Kobayashi held San Diego at bay in the ninth for his third save.

Sizemore put the Tribe on top in the first with a leadoff homer, ripping Banks' third pitch into the stands in right-center. Banks retired the next two batters before heavy rain began to fall and the game was delayed for two hours and 43 minutes.

After the tarp was finally lifted, Padres manager Bud Black left Banks in the game, and the righty retired Garko to end a half-inning that took nearly three hours to complete.

The bottom of the Cleveland lineup picked up two more runs in the third, as Casey Blake led off with a single and Shoppach followed with his fourth homer of the year, a blast to right.

San Diego got on the board against Sowers in the fourth, as Gonzalez and Tony Clark started the inning with singles before Gonzalez scored when Kouzmanoff doubled to right and Clark came in on Greene's groundout.

Trailing 3-2, Gonzalez's two-run homer moved the Padres in front in the fifth. Brian Giles poked a one-out single to right, and Gonzalez followed up with a blast over the wall in right to give San Diego a one-run lead.