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Final Score: Chicago Cubs 1 - San Francisco 2

San Francisco, CA (Sports Network) - Matt Cain hurled eight shutout innings, as the San Francisco Giants topped the Chicago Cubs, 2-1, in the second installment of a four-game series at AT&T Park.

Cain (5-6) fanned 10 Cubbies on just two hits and three walks for San Francisco, which has won three of four overall.

"He's only going to get better and I think he's learning how important it is to use his pitches and his command," Giants skipper Bruce Bochy said of Cain. "He was on, and a couple of games ago he threw a ballgame against a hot team. He had a rough outing and wasn't on his game, but he bounced back well and pitched another great game."

Fred Lewis was 2-for-4, scoring both San Francisco runs, including a swipe of home plate while Randy Winn recorded the team's lone RBI.

Cubs starter Jason Marquis (6-5) was exceptional in defeat, surrendering just two runs on four hits and three walks while fanning five through seven frames. The right-hander suffered his second straight loss after rattling off four straight wins.

"It was a well pitched game," Cubs manager Lou Pinella said. "Their guy pitched well and so did ours. Jason gives up two runs, four hits, goes seven innings, I'll take that every time. "We had a few chances, not too many, and didn't get it done."

Lee was 2-for-3 with a run scored while Geovany Soto picked up the lone RBI in the ninth for Chicago, which has dropped five of its last six.

The Cubs haven't won consecutive road games since taking two straight from Toronto at Rogers Centre from June 14-15.

San Francisco pushed a run across in the first. Lewis started the game with a single through the right side and Ray Durham followed with a walk. Lewis moved to third on a force out at second by Winn setting up a double steal of both home and second, as Soto went to second with the throw.

Lewis led off the sixth with a double and scored on a Winn RBI single two batters later.

Brian Wilson came on in the ninth, and allowed a leadoff triple from Lee to right-center. Lee crossed home when Soto lined an RBI single to center two batters later. Wilson recovered to retire Jim Edmonds on a fly ball before Mike Fontenot singled. Ryan Theriot went down swinging to end the game and hand Wilson his National League-best 23rd save.